![]() Also in this category would be orthobiologics that have stem cells derived from another person (allogeneic). There’s a body of research that shows that BMC (also known as BMAC or Bone Marrow Aspirate Concentrate) works better if it has a higher stem cell content (5). This is then centrifuged so that the stem cell fraction is concentrated (4). For example, Bone Marrow Concentrate is produced from bone marrow aspirate taken from the back of a patient’s pelvis. Stem cell containing orthobiologics are those that likely work through their stem cell content. This is a large molecule found in the blood that is believed to inhibit cartilage breakdown (3). Another orthobiologic here would be PPP with a specific cytokine that’s concentrated, like A2M. For example, PPP has been shown to help muscles heal (2). For example, platelet-poor plasma (PPP) is PRP without many platelets, which also contains different cytokines and growth factors in the plasma which also may aid healing. Also in this category would be serums and plasmas made from blood. These platelets produce growth factors that can assist in healing. In the blood-derived category, we have orthobiologics like a platelet-rich plasma which is made from concentrated platelets taken from the patients own blood. We can break orthobiologics into major tissue categories: What Type of Tissue is Being Used and How? For example, a product derived from birth tissues and used in an adult is a type of allogeneic orthobiologic. Allogeneic means that the orthobiologic comes from another patient. So for example, the doctor may take blood and then make platelet-rich plasma (PRP) and then re-inject that PRP into a damaged tendon in that same patient(1). What type of tissue is being used and how?Īutologous means that the orthobiologic comes from the same person in which it’s used.You can break orthobiologics down into two main categories: However, to really understand the scope of what’s meant by the term “orthobiologics”, let’s start breaking it all down into categories as these four natural substances are just the tip of the orthobiologics iceberg. These are autologous or allogeneic substances that can help bones, joints, muscles, or tendons heal if they are injected or placed surgically. Common orthobiologics include platelet-rich plasma, bone marrow concentrate, certain fat grafts, and birth tissues.
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